PREPARATION, CHARACTERIZATION, PHARMACOKINETIC, AND THERAPEUTIC POTENTIAL OF NOVEL 6-MERCAPTOPURINE-LOADED ORAL NANOMEDICINES FOR ACUTE LYMPHOBLASTIC LEUKEMIA

Preparation, Characterization, Pharmacokinetic, and Therapeutic Potential of Novel 6-Mercaptopurine-Loaded Oral Nanomedicines for Acute Lymphoblastic Leukemia

Yaru Zou,1,2,* Dong Mei,1,* Jinjie Yuan,1,2 Jiaqi Han,1 Jiamin Xu,1 Ning Sun,1 Huan He,1 Changqing Yang,2 Libo Zhao1 1Clinical Research Center, Beijing Children’s Hospital, Capital Medical University, National Center for Children’s Health, Beijing, 100045, People’s Republic of China; 2School of Basic Medicine and Clinical Pharmacy

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Inter- and intra-host sequence diversity reveal the emergence of viral variants during an overwintering epidemic caused by dengue virus serotype 2 in southern Taiwan.

Purifying selection during dengue viral infection has been suggested as the driving force of viral evolution and the higher complexity of the intra-host quasi-species is thought to offer an adaptive advantage for arboviruses as they cycle between arthropod and vertebrate hosts.However, very few studies have been performed to investigate the viral g

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A Survey of Universal Quantum von Neumann Architecture

The existence of universal quantum Stove Clockwork Timer computers has been theoretically well established.However, building up a real quantum computer system not only relies on the theory of universality, but also needs methods to satisfy requirements on other features, such as programmability, modularity, scalability, etc.To this end, here we stu

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Antifungal activity of non-conventional yeasts against Botrytis cinerea and non-Botrytis grape bunch rot fungi

Grapes harbour a plethora of non-conventional yeast species.Over the past two decades, several of the species have been extensively characterised and their contribution to wine quality is better understood.Beyond fermentation, some of the species have been investigated for their potential as alternative biological tools to reduce grape and wine spo

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